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Pharmacokinetic Parameters – To log transform or not to log transform
A proper analysis of pharmacokinetic (PK) data can have incredible implications. Something to think about is how the data should be prepared prior to any statistical analysis. This brings me to the goal of this post – to log or not to log, that is thy question. The short answer is yes, PK parameters should…
Cutaneous PK
So, in a previous post I spoke about systemic pharmacokinetics (PK) and you might be wondering how in the world cutaneous PK might be different. Well, it is and it isn’t – confusing right?. Systemic PK has been investigated and studied well over 100 years. Hypotheses have been tried and validated to develop the concepts…
The Cutaneous Anatomy
Before we dive into cutaneous pharmacokinetics (PK), methods to quantify API concentrations over time, and develop new concepts, we need to understand the cutaneous anatomy. If you are relatively unfamiliar with cutaneous PK, this will help when I mention specific stratifications, such as the stratum corneum or dermal adipocytes, in future posts. While this will…
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Pharmacokinetics with Ben Kuzma 